Photodynamic Anti-Tumor Efficiency of Hematoporphyrin Derivative
نویسندگان
چکیده
منابع مشابه
Pharmacological modulation of photodynamic therapy with hematoporphyrin derivative and light.
The interactions between photodynamic therapy (PDT) with hemotoporphyrin derivative (HPD) and treatment with cytotoxic drugs have been examined using both an in vitro tissue culture assay and an in vivo transplantable mouse tumor assay. Adriamycin (0.5-4.0 mg/kg) administered with HPD and at the time of irradiation potentiated the photodynamic effect, doubling the duration of tumor control. Adr...
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Hematoporphyrin derivative linked by ether bonds (HE) was synthesized by unambiguous procedures in order to compare its properties to hematoporphyrin derivative (HpD). Reverse phase high performance liquid and gel filtration chromatography were used to compare the HE derivatives to HpD. The cellular uptake of HE derivatives was compared to HpD using the WEHI 3B (D+) cell line and was shown to b...
متن کاملTumor-localizing components of the porphyrin preparation hematoporphyrin derivative.
Synthetic and analytical approaches were used to characterize the tumor-localizing components of the porphyrin preparation, hematoporphyrin derivative. From studies involving aqueous and nonaqueous gel exclusion and reverse-phase chromatography, we conclude that localization is mediated by hematoporphyrin derivative components which are among the most hydrophobic in the preparation. This appare...
متن کاملThermal considerations in murine tumor killing using hematoporphyrin derivative phototherapy.
Tumor cell killing utilizing hematoporphyrin derivative (HPD) phototherapy was studied in a murine tumor model to assess the relative importance of intratumor temperature in causing the tumoricidal effect. Temperature measurements and tumor killing without HPD strongly suggest that HPD phototherapy as reported previously by other workers has at least partially a hyperthermic effect. Also, it is...
متن کاملHistological study of the effect of hematoporphyrin derivative photodynamic therapy on the rat jejunum.
Hematoporphyrin derivative photodynamic therapy is evolving as a local treatment for neoplastic disease. The emphasis of previous research has been on the determination of mechanisms of tumoricidal activity and defining the tumoricidal porphyrin component in hematoporphyrin derivative. The effect of hematoporphyrin derivative photodynamic therapy on normal tissue has received little attention. ...
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ژورنال
عنوان ژورنال: Biomedical Journal of Scientific & Technical Research
سال: 2019
ISSN: 2574-1241
DOI: 10.26717/bjstr.2019.22.003769